Fruits extracts of Hovenia dulcis Thunb

Original research: http://dx.doi.org/10.1016/j.apjtm.2016.03.017

H. dulcis Thunberg (Rhamnaceae) is mainly found in China, Japan, and Korea, and is commonly used as a folk remedy in the form of tea and dietary supplements to promote health. Several reports suggested that the fruit of H. dulcis has detoxification properties on alcohol poisoning, hepatoprotective effect, anti-oxidant and antidiabetic activities [24–27]. Recently, the major biologically active components identified in the fruits of H. dulcis were myricetin and quercetin [23,27]. However, underlying mechanisms to explain the anti-inflammatory ef-fects of H. dulcis fruits remain unknown. In this study, we investigated the anti-inflammatory effects of the ethanol EHDF in LPS-induced mouse macrophage Raw 264.7 cells.